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KMID : 0043320110340101587
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Archives of Pharmacal Research
2011 Volume.34 No. 10 p.1587 ~ p.1591
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A new furostanol saponin from Asparagus cochinchinensis
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Shen Yang
Xu Cong Li
Xuan Wei Dong
Li Hui Liang
Liu Run Hui
Xu Xi Ke
Chen Hai Sheng
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Abstract
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A new furostanol saponin, (25S)-26-O-β-d-glucopyranosyl-5β-furost-20(22)-en-3β, 15β,26-triol-3-O-[α-l-rhamnopyranosyl-(1?4)]-β-d-glucopyranoside, namely, aspacochioside D (1) were isolated from Asparagus cochinchinensis (Lour.) Merr, along with three known saponins, aspacochioside C (2), (25S)-5β-spirostan-3β-yl-O-[O-α-l-rhamnopyranosyl-(1?4)]-β-d-glucopyranoside (3), and pseudoprotoneodioscin (4). The structure of 1 was elucidated on the basis of chemical reactions and spectral analysis (IR, GC, ESI-MS, 1H-NMR, 13C-NMR, DEPT, HMBC, HMQC and NOESY). The antiproliferative effects of 1?4 were evaluated in a cytotoxicity assay against the human tumor cell line, A549. Compound 2 (Aspacochioside C) exhibited moderate cytotoxicity against A-549, with an IC50 value of 3.87 μg/mL.
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KEYWORD
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Asparagus cochinchinensis, Furostanol glycosides, Cytotoxicity
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